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Integrated likelihood in light of de Finetti

13 January 2014 Leave a comment

Coletti, Giulianella; Scozzafava, Romano; Vantaggi, Barbara
Integrated likelihood in a finitely additive setting. (English summary) Symbolic and quantitative approaches to reasoning with uncertainty, 554–565, Lecture Notes in Comput. Sci., 5590, Springer, Berlin, 2009.
62A01 (62A99)

For an observed sample of data, the likelihood function specifies the probability or probability density of that observation as a function of the parameter value. Since each sample hypothesis corresponds to a single parameter value, the likelihood of any simple hypothesis is an uncontroversial function of the data and the model. However, there is no standard definition of the likelihood of a composite hypothesis, which instead corresponds to multiple parameter values. Such a definition could be useful not only for quantifying the strength of statistical evidence in favor of composite hypotheses that are faced in both science and law, but also for likelihood-based measures of corroboration and of explanatory power for epistemological research involving Popper’s critical rationalism or recent accounts of inference to the best explanation.
Interpreting the likelihood function under the coherence framework of de Finetti, this paper mathematically formulates the problem by defining the likelihood of a simple or composite hypothesis as a subjective probability of the observed data conditional on the truth of the hypothesis. In the probability theory of this framework, conditional probabilities given a hypothesis or event of probability zero are well defined, even for finite parameter sets. That differs from the familiar probability measures that Kolmogorov introduced for frequency-type probabilities, each of which, in the finite case, can only have zero probability mass if its event cannot occur. (The latter but not the former agrees in spirit with Cournot’s principle that an event of infinitesimally small probability is physically impossible.) Thus, in the de Finetti framework, the likelihood function assigns a conditional probability to each simple hypothesis, whether or not its probability is zero.
When the parameter set is finite, every coherent conditional probability of a sample of discrete data given a composite hypothesis is a weighted arithmetic mean of the conditional probabilities of the simple hypotheses that together constitute the composite hypothesis. In other words, the coherence constraint requires that the likelihood of a composite hypothesis be a linear combination of the likelihoods of its constituent simple hypotheses. Important special cases include the maximum and the minimum of the likelihood over the parameter set. They are made possible in the non-Kolmogorov framework by assigning zero probability to all of the simple hypotheses except those of maximum or minimum likelihood.
The main result of the paper extends this result to infinite parameter sets. In general, the likelihood of a composite hypothesis is a mixture of the likelihoods of its component simple hypotheses.

{For the entire collection see MR2907743 (2012j:68012).}

Reviewed by David R. Bickel

This review first appeared at “Integrated likelihood in a finitely additive setting” (Mathematical Reviews) and is used with permission from the American Mathematical Society.

Research topics in the Statomics Lab

1 November 2013 Leave a comment
Categories: Contributions, Methods

Coherent fiducial distributions

20 August 2013 Leave a comment

Small dimensional empirical Bayes inference

9 May 2013 Leave a comment

D. R. Bickel, “Simple estimators of false discovery rates given as few as one or two p-values without strong parametric assumptions,” Statistical Applications in Genetics and Molecular Biology 12, 529–543 (2013). 2011 version | erratum

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To address multiple comparison problems in small-to-high-dimensional biology, this paper introduces estimators of the local false discovery rate (LFDR), reports their main properties, and illustrates their use with proteomics data. The new estimators have the following advantages:

  1. proven asymptotic conservatism;
  2. simplicity of calculation without the tuning of smoothing parameters;
  3. no strong parametric assumptions;
  4. applicability to very small numbers of hypotheses as well as to very large numbers of hypotheses.

The link to the erratum was added 31 March 2015.

Profile likelihood & MDL for measuring the strength of evidence

8 April 2013 Leave a comment

Estimates of the local FDR

13 February 2013 Leave a comment

Z. Yang, Z. Li, and D. R. Bickel, “Empirical Bayes estimation of posterior probabilities of enrichment: A comparative study of five estimators of the local false discovery rate,” BMC Bioinformatics 14, art. 87 (2013). published version |  2011 version | 2010 version

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This paper adapts novel empirical Bayes methods for the problem of detecting enrichment in the form of differential representation of genes associated with a biological category with respect to a list of genes identified as differentially expressed. Read more…

Optimal strength of evidence

13 February 2013 Leave a comment

D. R. Bickel, “Minimax-optimal strength of statistical evidence for a composite alternative hypothesis,” International Statistical Review 81, 188-206 (2013). 2011 version | Simple explanation (added 2 July 2017)

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This publication generalizes the likelihood measure of evidential support for a hypothesis with the help of tools originally developed by information theorists for minimizing the number of letters in a message. The approach is illustrated with an application to proteomics data.

MLE of the local FDR

13 February 2013 Comments off

Confidence levels as degrees of belief

13 February 2013 Leave a comment

D. R. Bickel, “A frequentist framework of inductive reasoning,” Sankhya A 74, 141-169 (2013). published version | 2009 version cda_displayimage| relationship to a working paper | simple explanation (added 17 July 2017)

A confidence measure is a parameter distribution that encodes all confidence intervals for a given data set, model, and pivot. This article establishes some properties of the confidence measure that commend it as a viable alternative to the Bayesian posterior distribution.

Confidence (correct frequentist coverage) and coherence (compliance with Ramsey-type restrictions on rational belief) are both presented as desirable properties. The only distributions on a scalar parameter space that have both properties are confidence measures.

Local FDR estimation for low-dimensional data

18 October 2012 Leave a comment

M. Padilla and D. R. Bickel, “Estimators of the local false discovery rate designed for small numbers of tests,” Statistical Applications in Genetics and Molecular Biology 11 (5), art. 4 (2012). Full article | 2010 & 2012 preprints

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This article describes estimators of local false discovery rates, compares their biases for small-scale inference, and illustrates the methods using a quantitative proteomics data set. In addition, theoretical results are presented in the appendices.