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Archive for the ‘ontology’ Category

Estimates of the local FDR

13 February 2013 Comments off

Z. Yang, Z. Li, and D. R. Bickel, “Empirical Bayes estimation of posterior probabilities of enrichment: A comparative study of five estimators of the local false discovery rate,” BMC Bioinformatics 14, art. 87 (2013). published version |  2011 version | 2010 version

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This paper adapts novel empirical Bayes methods for the problem of detecting enrichment in the form of differential representation of genes associated with a biological category with respect to a list of genes identified as differentially expressed. Read more…

Local FDR estimation software

30 June 2012 1 comment

LFDRenrich is a suite of R functions for the estimation of local false discovery rates by maximum likelihood under a two-component or three-component parametric mixture model of 2X2 tables such as those used in gene enrichment analyses.

LFDRhat is a more general suite of R functions for the estimation of local false discovery rates by maximum likelihood under a two-component or three-component parametric mixture model.

Estimating probabilities of enrichment

4 January 2012 Comments off

Z. Yang, Z. Li, and D. R. Bickel, “Empirical Bayes estimation of posterior probabilities of enrichment,” Technical Report, Ottawa Institute of Systems Biology, Technical Report, Ottawa Institute of Systems Biology, arXiv:1201.0153 (2011). Full preprint | 2010 seed

This paper adapts novel empirical Bayes methods for the problem of detecting enrichment in the form of differential representation of genes associated with a biological category with respect to a list of genes identified as differentially expressed. A microarray case study illustrates the methods using Gene Ontology (GO) terms, and a simulation study compares their performance. We report that which enrichment methods work best depends strongly on how many GO terms or other biological categories are of interest.

Quantifying evidence for enrichment

7 January 2011 Comments off

Z. Yang and D. R. Bickel, “Minimum description length measures of evidence for enrichment,” Technical Report, Ottawa Institute of Systems Biology, COBRA Preprint Series, Article 76, available at biostats.bepress.com/cobra/ps/art76 (2010). Full preprint