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Observed confidence levels for microarrays, etc.

22 June 2011

D. R. Bickel, “Estimating the null distribution to adjust observed confidence levels for genome-scale screening,” Biometrics 67, 363-370 (2011). Abstract and article | French abstract | Supplementary material

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This paper describes the first application of observed confidence levels to data of high-dimensional biology. The proposed method for multiple comparisons can take advantage of the estimated null distribution without any prior distribution. The new method is applied to microarray data to illustrate its advantages.